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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: ASB2 is a direct target of FLI1 that sustains NF-κB pathway activation in germinal center-derived diffuse large B-cell lymphoma

Fig. 2

Pathway analysis following FLI1 downregulation and genomic distribution of FLI1 binding sites identified by ChIP-Seq. A Summary of pathways enriched in FLI1 up- (red) or downregulated (blue) genes after RNA-Seq, comparing FLI1 knockdown versus control samples in the GCB DLBCL cell lines OCI-Ly1 and VAL (absolute logfold change > 0.1 and adj.P < 0.05). Significant g:GOSt annotated pathways/signatures (adjusted p-value < 0.05) are grouped into biological processes and sorted by adjusted p-value. B Distribution of FLI1 binding sites as assessed by ChIP-Seq in both GCB DLBCL cell lines. C Consensus binding motif enrichment found with MEME for all 16,865 OCI-Ly1 peaks plus the top 16,865 VAL peaks or for the promoter only OCI-Ly1 plus VAL peaks

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