Fig. 1
From: Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
Model of USP37 switching in different stages of the cell cycle. USP37 levels fluctuate during cell cycle progression. The anaphase-promoting complex (APC) targets cell cycle proteins for proteasomal degradation through coactivators. A In the late G1 stage, USP37 expression is found to be elevated as it is being phosphorylated by cdk2 and stabilized by the E2F transcription factor. However, Cdk2 also phosphorylates a coactivator of APC Complex i.e., CDH1, which together with EMI1 negatively regulates APC complex resulting in the accumulation of USP37 that detours APC/C and stabilizes cyclin A through deubiquitination, required for G1/S phase transition. B In the late G2/M phase, USP37 acts as a substrate of the APC/C complex via phosphorylation by PLK1 and is further ubiquitinated by βTrCP for the biphasic degradation, resulting in the downregulation of USP37, necessary for the G2/M phase transition