Fig. 4
From: Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
Molecular mechanism of USP37-mediated tumor suppression in medulloblastoma cells. Blue box indicates the condition during which USP37 expression is elevated due to low level of REST protein in neural cells. The Green box indicates the tumor microenvironment conditions in medulloblastoma in which USP37 activity is repressed by methylation of the USP37 promoter due to increased REST protein levels