Table 1 List of USP37 specific target substrates with their mechanistic role in different cellular pathways

Cell Cycle Regulation

Cyclin A

Critical for the G1/S transition

[19, 24]

p27

Inhibition of cell cycle progression

[86]

Oncogenesis

PLZF moiety of PLZF/RARA fusion

Cell transformation in PLZF/RARA-associated APL

[25]

c-MYC

Cell proliferation

[26]

14–3-3γ

Cell transformation, and promotes cell migration and invasion.

[27]

HIF2α

Angiogenesis, glycolysis, and glucose transport and erythropoiesis.

[28]

DNA replication and DNA damage response (DDR)

BRCA1-A complex

HR pathway of DNA repair

[42]

Cdt1

Dynamics of DNA replication

[32, 48]

Epithelial-mesenchymal transition and Metastasis

Gli 1

EMT via Hedgehog (Hh) pathway

[39, 40]

SNAI1

Cancer cell migration and EMT mediated metastasis

[62,63,64]

Chromosomal cohesion and mitotic progression

Cohesin complex (SMC3, SMC1, SSCC1, SA1&2)

Chromosome’s segregation and cohesion, spindle assembly, and further mitotic progression

[76, 80]

WAPL