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Table 1 List of USP37 specific target substrates with their mechanistic role in different cellular pathways

From: Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells

Pathways Target substrate Mechanistic role Ref.
Cell Cycle Regulation Cyclin A Critical for the G1/S transition [19, 24]
p27 Inhibition of cell cycle progression [86]
Oncogenesis PLZF moiety of PLZF/RARA fusion Cell transformation in PLZF/RARA-associated APL [25]
c-MYC Cell proliferation [26]
14–3-3γ Cell transformation, and promotes cell migration and invasion. [27]
HIF2α Angiogenesis, glycolysis, and glucose transport and erythropoiesis. [28]
DNA replication and DNA damage response (DDR) BRCA1-A complex HR pathway of DNA repair [42]
Cdt1 Dynamics of DNA replication [32, 48]
Epithelial-mesenchymal transition and Metastasis Gli 1 EMT via Hedgehog (Hh) pathway [39, 40]
SNAI1 Cancer cell migration and EMT mediated metastasis [62,63,64]
Chromosomal cohesion and mitotic progression Cohesin complex (SMC3, SMC1, SSCC1, SA1&2) Chromosome’s segregation and cohesion, spindle assembly, and further mitotic progression [76, 80]
WAPL