Fig. 1
From: Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer
Different molecular subtypes of breast cancer have different metastatic organotropism and BCSCs features. Luminal A breast cancer with a low proportion of BCSCs tends to bone metastasis. Luminal B breast cancer with a low proportion of BCSCs tends to metastasis of bone and liver. HER2 enriched breast cancer with a high proportion of ALDH+/Epithelial-like BCSCs tends to metastasis of lung, brain and liver. Triple negative breast cancer with a high proportion of CD24- CD44+/Mesenchymal-like BCSCs tends to metastasis of lung, brain and distant nodes