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Table 1 Heterogeneity of BCSCs

From: Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer

Heterogeneity

Biological characteristics

Genetic characteristics

Biomarker

status

CD24- CD44+

BCSCs

Tumor invasive edge;

Highly invasive; [10]

Great tumor-initiating capacity:100 cells [11]

Over-expressed genes:IGFBP1, ST8SIA2, PLD5, SCG5, MYOT;

KEGG enrichment:focal adhesion, PI3K-AKT signaling [12]

ALDH+

BCSCs

Center of tumor;

Highly proliferative; [10]

Great tumor-initiating capacity:500 cells [13]

Over-expressed genes:WNT2,IGF1,DLL1;

KEGG enrichment:ribosome, oxidative phosphorylation, proteasome; [12]

Mutation:BRCA1 mutation [14]

CD24- CD44+

& ALDH+

BCSCs

The greatest tumor-initiating capacity:20 cells [13]

-

Epithelial/

mesenchymal

status

Epithelial-like

BCSCs

Resemble luminal stem cells of normal mammary gland;

Identified by ALDH+;

Highly proliferative;

Mediate colonization of metastatic foci [10]

Up-regulated MET-related genes:CDH1, OCLN, CLDN [15]

Mesenchymal-like

BCSCs

Resemble basal stem cells of normal mammary gland;

Identified by CD24- CD44+;

Highly invasive;

Mediate tumor invasion into blood circulation [10]

Up-regulated EMT-related genes:VIM, ZEB1, ZEB2 [15]

  1. BCSCs breast cancer stem cells