Fig. 8From: PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cellsAn illustration shows that PGRMC1 expression promotes ferroptosis in PCC. PCC has increased PGRMC1 expression related to increased free fatty acid acids (FFA), lipid droplets (LD), and fatty acid oxidation (FAO). PGRMC1 expression increased FAO and ferroptosis sensitivity by xCT inhibitors via lipophagy and tubulin detyrosinationBack to article page