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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: BUB1 drives the occurrence and development of bladder cancer by mediating the STAT3 signaling pathway

Fig. 1

BUB1 expression was increased in human bladder cancer. A. Volcano plot of differentially expressed genes (DEGs) in TCGA BLCA data. B. Box plots of the relative mRNA expression levels of BUB1 in human bladder cancer samples from TCGA datasets. The boxes show that the expression level of BUB1(n = 19) in normal bladder tissue was lower than that (n = 411) in bladder cancer tissue. P < 0.0001. C. Real-time PCR analysis of BUB1 mRNA levels in tissue derived from 34 paired bladder cancer specimens. P < 0.001. D. Immunohistochemical (IHC) analysis of the BUB1 protein in human normal bladder and bladder cancer clinical samples. Quantification of IHC staining in human normal bladder and bladder cancer clinical samples. E. WB analysis of the BUB1 protein level in human normal bladder (N) and bladder cancer (T) clinical samples. F. Comparison of survival rates in the indicated groups. Low BUB1 expression group, n = 14; high BUB1 expression group, n = 20. Patients with high expression of BUB1 had a significantly worse prognosis than those with low expression of BUB1 (P = 0.0084); n: number of patients. G. Immunofluorescence staining showing the correlation between BUB1 localization and CK5 and CK8 localization in bladder cancer tissue

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