Fig. 4From: The IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic glycolysisDownregulation of CENP-N inhibited cell proliferation and glucose metabolism in vivo. a General view of tumor formation in nude mice. b The tumor volume curve of nude mice bearing tumors formed from 5-8F shCENP-N cells, CEN-2Z shCENP-N cells and the corresponding control cells. c Nude mice bearing tumors formed from 5-8F shCENP-N cells, CEN-2Z shCENP-N cells and the corresponding control cells. d The average tumor weight in nude mice bearing tumors formed from 5-8F shCENP-N cells, CEN-2Z shCENP-N cells and the corresponding control cells. e A representative PET-CT image was used to detect glucose uptake in 5-8F shCENP-N and CEN-2Z shCENP-N xenografts and the corresponding controls. f SUVmax values in nude mice bearing tumors. g SUVmean values in nude mice bearing tumors. h TLG values in nude mice bearing tumors. The data are shown as the mean ± SD values. * p < 0.05, ** p < 0.01Back to article page