Fig. 8

CENP-N promotes cell proliferation, cell cycling and apoptosis resistance by increasing aerobic glycolysis in NPC cells. a Changes in relative glucose uptake in two NPC cell lines were detected after CENP-N overexpression and GSK2837808A treatment. b Changes in lactic acid production in two NPC cell lines were detected after CENP-N overexpression and GSK2837808A treatment. c A CCK-8 assay was used to detect changes in cell viability after CENP-N overexpression and GSK2837808A treatment in two NPC cell lines. d Clone formation assay was used to detect the changes in cell proliferation after CENP-N overexpression and GSK2837808A treatment in two NPC cell lines. e The percentage of apoptotic cells was determined in two NPC cell lines after CENP-N overexpression and GSK2837808A treatment. f Changes in the cell cycle distribution in two NPC cell lines after CENP-N overexpression and GSK2837808A treatment. g Model showing the action mechanism of CENP-N in NPC. The data are shown as the mean ± SD values. * p < 0.05, ** p < 0.01, ***p < 0.001