Fig. 7

Selective inhibition of cellular glycolysis by mannose. a-c The indicated cells were treated with mannose or sterilized water (Control) for 36 h. The ECAR was measured three times at basal state, sequential injection of glucose, oligomycin and 2-deoxy-D-glucose (upper panels). The levels of glycolysis, glycolytic capacity and glycolytic reserve were calculated and presented in the lower panels. d-f PMI or ZIP10 knockdown-8305C cells and control cells were treated with mannose or sterilized water for 36 h. The ECAR was measured three times at basal state, sequential injection of glucose, oligomycin and 2-deoxy-D-glucose (upper panels). The levels of glycolysis, glycolytic capacity and glycolytic reserve were calculated and presented in the lower panels. The data were presented as mean ± SD. Statistically significant differences were indicated: *, P < 0.05; **, P < 0.01; ***, P < 0.001