Fig. 8
Schematic presentation of the study.Briefly, elevated-global m6A levels that determined by upregulated-METTL3 and downregulated-ALKBH5 facilitate m6A methylation of mRNA, such as ENO1 in LUAD. M6A reader YTHDF1 is prone to interact with m6A-methylated ENO1 mRNA, by which leads to a stimulation of ENO1 translation. Increased ENO1 in turn causes reinforcement in glycolysis and tumor growth in LUAD