Fig. 6

CB-839 and CPI-613 inhibit tongue tumor growth in mice more potently when combined. A The effects of CB-839 and CPI-613 alone or in combination on tongue tumor shrinkage on Day 14 after treatment. B Histology of major organs (e heart, intestine, kidney, liver, and lung) at the endpoint of each treatment. C Ki67 positive tumor cells in tongue xenografts of mice receiving indicated treatments determined by IHC. D Apoptosis in tongue xenografts of mice receiving indicated treatments determined by TUNEL assay. E Schematic representation of the mechanism of drug combination-mediated inhibition of head and neck tumor growth. In (A, C, D), representative images and quantitative data are shown in the left and right panels, respectively. *p < 0.05, **p < 0.01