Fig. 1

The evaluation of clinical importance of miR-23a-3p. A Dendrogram of miRNAs clustered based on a dissimilarity measure (1-TOM) through WGCNA analysis. B Module member count, ME-clinical traits correlation (Pearson) and P-value indicated for each module. C Scatterplots showing the correlations between gene module membership in the blue module and gene significance for cirrhosis. D A dot plot showing the ranking of miRNAs according to their log2 fold change. E Progression-free survival curve of miR-23a-3p in HCC patients treated with sorafenib. Data were gathered from the GSE56059. F Representative images of miR-23a-3p and DAPI staining in the human HCC tissue microarray. G Increased miR-23a-3p expression observed in recurrent HCC, P = 0.0345. H OS and I RFS outcomes based on Kaplan-Meier survival analysis. The increased expression of miR-23a-3p was significantly associated with poor OS and DFS with P-values 0.0190 and 0.0184, respectively. F Multivariate Cox analysis showing the association between clinicopathologic factors and HCC patient survival outcome. The expression of MiR-23a-3p is significant only in RFS. **P < 0.01, *P < 0.05