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Table 1 The level of serum lipid, ERRα and TFEB in tissue microarray of EC patients and controls

From: Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression

Parameter (N=111)

TG

  p

CHOL

  p

HDL

  p

APO-A

  p

LDL

  p

APO-B

  p

TFEB

ERRα

-/+

++

+++

  p

-/+

++

+++

 p

Normal

(n=32)

1.027±0.882

0.032

4.623±0.853

0.649

1.599±0.412

0.041

1.331±0.229

0.026

2.709±0.830

0.568

0.834±0.229

0.157

24

8

0

<0.001

27

5

0

<0.001

EC

(n=79)

1.549±1.369

4.723±1.032

1.394±0.428

1.207±0.226

2.578±0.929

0.924±0.338

26

38

15

14

55

10

Stage I-II

(n=62)

1.556±1.538

0.859

4.703±1.133

0.192

1.388±0.470

0.980

1.191±0.224

0.691

2.693±0.985

0.178

0.935±0.381

0.785

19

31

12

0.710

13

41

8

0.328

Stage III-IV

(n=17)

1.622±1.019

5.055±0.719

1.386±0.234

1.218±0.210

3.148±0.636

0.958±0.236

7

7

3

1

14

2

MI <50%

(n=55)

1.597±1.531

0.589

4.742±1.064

0.806

1.388±0.463

0.827

1.196±0.219

0.550

2.593±0.979

0.880

0.936±0.362

0.618

21

29

5

0.003

14

35

6

0.024

MI ≥50%

(n=24)

1.445±0.933

4.680±0.979

1.408±0.350

1.231±0.244

2.553±0.869

0.898±0.282

5

9

10

0

20

4

EEC

(n=63)

1.515±1.397

0.592

4.790±1.056

0.184

1.424±0.452

0.120

1.218±0.225

0.390

2.706±0.976

0.021

0.950±0.353

0.100

20

32

11

0.613

13

41

9

0.216

NEEC

(n=16)

1.711±1.256

4.412±0.887

1.274±0.301

1.162±0.232

2.133±0.578

0.819±0.254

6

6

4

1

14

1

LNM

(n=9)

1.605±1.447

0.316

4.724±1.059

0.729

1.367±0.421

0.046

1.193±0.223

0.151

2.640±0.946

0.092

0.925±0.351

0.984

5

2

2

0.232

1

7

1

0.842

No-LNM

(n=70)

1.413±0.380

4.836±0.812

1.637±0.439

1.326±0.242

1.980±0.666

0.923±0.253

21

36

13

13

48

9

  1. Abbreviations: APO-A Apolipoprotein A, APO-B Apolipoprotein B, CHOL Cholesterol, ERRα Estrogen-Related Receptor α, EC Endometrial Cancer, EEC Endometrioid Endometrial Cancer, HDL High-Density Lipoprotein, LDL Low-Density Lipoprotein, LNM Lymph Node Metastasis, MI Myometrial Invasion, NEEC Non-Endometrioid Endometrial Cancer, TG total Triglyceride, TFEB Transcription Factor EB. p < 0.05 suggests significantly different