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Table 1 The level of serum lipid, ERRα and TFEB in tissue microarray of EC patients and controls

From: Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression

Parameter (N=111) TG   p CHOL   p HDL   p APO-A   p LDL   p APO-B   p TFEB ERRα
-/+ ++ +++   p -/+ ++ +++  p
Normal
(n=32)
1.027±0.882 0.032 4.623±0.853 0.649 1.599±0.412 0.041 1.331±0.229 0.026 2.709±0.830 0.568 0.834±0.229 0.157 24 8 0 <0.001 27 5 0 <0.001
EC
(n=79)
1.549±1.369 4.723±1.032 1.394±0.428 1.207±0.226 2.578±0.929 0.924±0.338 26 38 15 14 55 10
Stage I-II
(n=62)
1.556±1.538 0.859 4.703±1.133 0.192 1.388±0.470 0.980 1.191±0.224 0.691 2.693±0.985 0.178 0.935±0.381 0.785 19 31 12 0.710 13 41 8 0.328
Stage III-IV
(n=17)
1.622±1.019 5.055±0.719 1.386±0.234 1.218±0.210 3.148±0.636 0.958±0.236 7 7 3 1 14 2
MI <50%
(n=55)
1.597±1.531 0.589 4.742±1.064 0.806 1.388±0.463 0.827 1.196±0.219 0.550 2.593±0.979 0.880 0.936±0.362 0.618 21 29 5 0.003 14 35 6 0.024
MI ≥50%
(n=24)
1.445±0.933 4.680±0.979 1.408±0.350 1.231±0.244 2.553±0.869 0.898±0.282 5 9 10 0 20 4
EEC
(n=63)
1.515±1.397 0.592 4.790±1.056 0.184 1.424±0.452 0.120 1.218±0.225 0.390 2.706±0.976 0.021 0.950±0.353 0.100 20 32 11 0.613 13 41 9 0.216
NEEC
(n=16)
1.711±1.256 4.412±0.887 1.274±0.301 1.162±0.232 2.133±0.578 0.819±0.254 6 6 4 1 14 1
LNM
(n=9)
1.605±1.447 0.316 4.724±1.059 0.729 1.367±0.421 0.046 1.193±0.223 0.151 2.640±0.946 0.092 0.925±0.351 0.984 5 2 2 0.232 1 7 1 0.842
No-LNM
(n=70)
1.413±0.380 4.836±0.812 1.637±0.439 1.326±0.242 1.980±0.666 0.923±0.253 21 36 13 13 48 9
  1. Abbreviations: APO-A Apolipoprotein A, APO-B Apolipoprotein B, CHOL Cholesterol, ERRα Estrogen-Related Receptor α, EC Endometrial Cancer, EEC Endometrioid Endometrial Cancer, HDL High-Density Lipoprotein, LDL Low-Density Lipoprotein, LNM Lymph Node Metastasis, MI Myometrial Invasion, NEEC Non-Endometrioid Endometrial Cancer, TG total Triglyceride, TFEB Transcription Factor EB. p < 0.05 suggests significantly different