Fig. 1

Expression and clinical significance of m6A regulators in HNSCC. (A and B) Heatmap and violin plots show the mRNA expression levels of 20 m6A regulators in 502 HNSCC and 44 normal tissues according to TCGA data. Red and blue colors illustrate relatively high and low expression, respectively. **P < 0.01, ***P < 0.001, ns: not statistically significant. C The survival map of 20 m6A-related regulators in pan-cancer generated by GEPIA2 online website. D The OS probability of HNSCC patients with high vs. low expression of IGF2BP2. The quartile expression level of IGF2BP2 was used as cutoff value. Group 1: the upper quartile was considered as IGF2BP2 ^high. Group 2: the lower quartile was considered as IGF2BP2 ^low. E Multivariate cox regression analysis of IGF2BPs and clinical parameters to identify the independent prognostic factors. F The nomogram for prediction of the 1-, 3-, and 5-year OS of HNSCC patients. G The calibration curve for the OS nomogram model. The ideal nomogram is represented by a dashed diagonal line, and the blue, red, and orange lines symbolize the 1-, 3-, and 5-year observed nomograms