Skip to main content
Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Fig. 3

IGF2BP2 promotes metastatic behaviour of HNSCC cells in vitro. A-B The efficiency of knockdown and overexpression of IGF2BP2 was validated by RT-qPCR (A) and western blot (B) at mRNA as well as protein levels in FaDu and SCC15 cells. GAPDH served as an internal control. ***P < 0.001, ****P < 0.0001, ns: not statistically significant. C-D Images representing wound healing (C) and transwell assays (D) showing the mobility and invasiveness of HNSCC cells after knockdown or overexpression of IGF2BP2. Lower right panel shows the statistical data of cell migration distance, and migrated and invaded cell counts. *P < 0.05, **P < 0.01, ***P < 0.001. All the data are presented in the form of mean ± SD from three independently performed experiments

Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us