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Table 2 Univariate analysis and multivariate analysis of IGF2BP2 expression and clinicopathologic variables in patients with HNSCC Cox-regression analysis

From: RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Variables

Univariate analysis

Multivariate analysis

HR (95%CI)

P Value

HR (95%CI)

P Value

IGF2BP2

2.254 (1.160-4.381)

0.017*

2.206 (1.065-4.568)

0.033*

Age

1.006 (0.545-1.857)

0.983

1.154 (0.594-2.244)

0.672

Gender

0.607 (0.145-2.538)

0.494

0.469 (0.101-2.172)

0.333

T classification

1.157 (0.554-2.416)

0.698

1.087 (0.496-2.382)

0.836

Tumor differentiation

1.164 (0.608-2.226)

0.647

1.049 (0.528-2.084)

0.892

LNM

2.915 (1.295-6.559)

0.010*

2.555 (1.082-6.033)

0.032*

Extranodal extension

0.704 (0.296-1.678)

0.429

0.978 (0.065-1.568)

0.653

  1. Abbreviations: IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2, HNSCC Head and neck squamous carcinoma cells, HR Hazard ratio, CI Confidence interval, LNM Lymph node metastasis.
  2. Variables: IGF2BP2: high vs low; Age: ≥60 (y) vs<60 (y); Gender: male vs female; T classification: T1/T2 vs T3/T4; Tumor differentiation: well/moderate vs poor; LNM: N0 vs N1/N2/N3; Extranodal extension: no vs yes. *P < 0.05.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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