Fig. 4

CRS and its risk factors. A The adverse events after BCMA-CD38 CAR-T infusion. B The rates of different CRS grades. C The peak cytokine levels (IL-6, Ferritin and CRP) between CRS grade ≥ 3 and CRS grade <3 were compared. Mann-Whitney test was used for statistical comparison. D The risk factors (MIg, β2MG, doses of CAR-T infusion, light chain, and the percentages of CD38+ and BMCA+ plasma in bone marrow) at baseline were compared between CRS grade ≥ 3 and CRS grade <3. Mann-Whitney test was used for statistical comparison. E The amplification curves and peak values of CAR+ T cells in peripheral blood of patients assessed by FCM were compared between CRS grade ≥ 3 and CRS grade <3 after CAR-T cells infusion. Mann-Whitney test was used for statistical comparison