Fig. 4From: INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinomaINPP5F upregulates the expression of c-MYC and cyclin E1 in HCC. A Heat map of DEGs associated with cell growth. The DEGs were obtained from SK-Hep1-Ctrl and SK-Hep1-shINPP5F through RNA-seq. B The mRNA and (C) protein expression of c-MYC and cyclin E1 in HCC cell lines with INPP5F knockdown or overexpression. D INPP5F, c-MYC and cyclin E1 staining were conducted in serial sections of tumors from subcutaneous xenograft model using INPP5F stable knockdown MHCC-97H and its control cells. E The impact of c-MYC and cyclin E1 knockdown on INPP5F-mediated cell proliferation was determined by colony formation assays. Data is presented as means ± standard error for three independent experiments, *P < 0.05, ns: not significant. Scale bar: 100 umBack to article page