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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop

Fig. 8

M1-like TAMs cascade the EMT/CSCs regulation of OSCC cells through the Jak/Stat3/THBS1 pathway. A. Venn diagram for the up-regulated differential expression genes shared by each filtered GO analysis; B. An increased expression of THBS1 by the activation of Stat3 in OSCC cells treated with CM from M1-like TAMs; C. Increased expression of THBS1 in the OSCC xenografts treated with CM from M1-like TAMs (200x); D. Increased expression of THBS1 in the exosomes derived from OSCC cells treated with CM from M1-like TAMs; E. Bioinformatics analyses indicating a significantly positive correlation between THBS1 expression and CD80/CD86/IL6 expression in the TCGA HNSCC cohort; F. Promoter prediction indicating the expression of THBS1 targeted by Stat3; G. ChIP assays were performed in OSCC cells after treatment with CM from M0 and M1-like TAMs for 30min; H. The correlation between STAT3 activation and THBS1 expression in OSCC samples, the immunoreactivity scores were recorded by multiplying the staining intensity and the percentage of positive cancer cells (n=40, 200x, p< 0.01); I. Bioinformatics analyses for the expression correlation between THBS1 and EMT related genes based on the TCGA primary HNSCC cohort; J. Bioinformatics analyses for the expression correlation between THBS1 and CSC related genes based on the TCGA primary HNSCC cohort

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