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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer

Fig. 2

MiR-423-5p interacts with MALAT1 in prostate cancer cell lines. A Schematic representation of the bioinformatic method (TargetScan) used to identify miRNA-423-5p binding sites on the MALAT1. B, C Plasmids used to generate Firefly luciferase expressing vectors under the control of unmutated and mutated miRNA-423-5p binding sites on the MALAT1 (Upper panels). Graphs representing the relative expression of FL/RL using vectors under the control of unmutated and mutated miRNA-423-5p binding sites on the MALAT1 (Lower panels). D Representative images of MALAT1 and miR-423-5p expression in the prostate cancer cell lines LNCaP and PC3 using the proximity ligation assay (PLA) (Left panels). Graphs representing the number of dots that were detected by PLA in LNCaP and PC3 cells

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