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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer

Fig. 4

Effect of miR-423-5p mimic expression on cell proliferation, migration, and invasion of PC3 and LNCaP prostate cancer cell lines. A, B Graphs representing the effect of miR-423-5p mimic expression on cell proliferation of PC3 and LNCaP prostate cancer cells at 24 and 48 h. P = ns (24 h), *p = 0.0427 (48 h), *p = 0.0184 (24 h) and *p = 0.0431 (48 h). C, D Graphs representing the effect of miR-423-5p mimic expression on cell migration of PC3 and LNCaP prostate cancer cells using the scratch assay. **P = 0.0018 and *p = 0.00479. E, F Graphs representing the effect of miR-423-5p mimic expression on cell migration of PC3 and LNCaP prostate cancer cells using the transwell assay. *P = 0.0114 and *p = 0.0135. G, H Graphs representing the effect of miR-423-5p mimic expression on cell invasion of PC3 and LNCaP prostate cancer cells using the transwell invasion assay. *P = 0.0304 and *p = 0.0492. Representative images of migration in Boyden chambers of I (empty vector) and J miR-423-5p mimic expressing PC3 cells after 48 h and crystal violet labeling. K Graphs representing the effect of miR-423-5p mimic expression on cell migration of PC3 cells. * P = 0.049. Representative images of invasion in Boyden chambers of L (empty vector) and M miR-423-5p mimic expressing PC3 cells after 48 h and crystal violet labeling. N Graphs representing the effect of miR-423-5p mimic expression on cell invasion of PC3 cells. ** P = 0.006

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