Table 1 Summary of what is known about the FL epigenome

1) FL is addicted to epigenetic mutations, thus representing a good model of epi-cancer.

2) The most frequent epigenetic mutations in FL concerns genes that regulate the deposition of histone marks.

3) Most epigenetic mutations occur early in FL lymphomagenesis.

4) Mutations in the epigenetic regulators KMT2D, CREBBP and EZH2 affect the FL microenvironment.

5) Combination therapies targeting the FL epigenome and its immunological synapse represent promising future approaches for FL management.