From: The follicular lymphoma epigenome regulates its microenvironment
1) How do mutations in the epigenetic genes KMT2D, CREBBP and EZH2 (concomitantly or alone) orchestrate and promote the multi-scale (e.g. genetic, molecular, cellular) alterations that drive lymphomagenesis and CPC establishment in FL? | |
2) What is the clonal evolution of CPC during FL course? How to properly define (in space and time) and target this population? | |
3) How does FL develop from aberrant GC reactions driven by EZH2 mutant-mediated reprogramming of the microenvironment? | |
4) How do the epigenetic regulator-TME bidirectional crosstalk interfere with the therapeutic response in FL? | |
5) Would it be possible to combine epigenetic modifiers that target tumor cells and non-tumor cells in the FL TME? If yes, what combination would be the best for long-term efficacy and complete cure? |