Descriptive Statistics | Normal Group Norm (n = 10) | Mild Group Mild (n = 6) | Moderate Group Mod (n = 3) | Severe Group Sev (n = 3) | |
---|---|---|---|---|---|
Cmax (ng/mL) | Geo mean (%CV) Mean (±SD) | 26.2 (31.4) 27.6 (±8.7) | 26.2 (53.8) 29.5 (±15.9) | 16.8 (12.6) 16.9 (±2.1) | 15.3 (43.6) 16.3 (±7.1) |
Cmin (ng/mL) | Geo mean (%CV) Mean (±SD) | 14.4 (29.8) 15.1 (±4.5) | 10.8 (57.3) 12.1 (±7.0) | 10.4 (22.4) 10.5 (±2.4) | 7.6 (32.3) 7.9 (±2.5) |
Cavg (ng/mL) | Geo mean (%CV) Mean (±SD) | 18.7 (28.1) 19.5 (±5.5) | 14.7 (51.9) 16.2 (±8.4) | 13.0 (8.1) 13.0 (±1.1) | 9.5 (36.4) 10.0 (±3.6) |
AUC0 − 24 (hr*ng/mL) | Geo mean (%CV) Mean (±SD) | 449.5 (28.1) 468.8 (±132.0) | 352.1 (51.9) 387.7 (±201.3) | 311.0 (8.1) 311.7 (±25.2) | 228.9 (36.4) 239.5 (±87.1) |
CLssF (mL/hr) | Geo mean (%CV) Mean (±SD) | 4449.0 (36.0) 4675.0 (±1683.6) | 5680.0 (45.5) 6200.0 (±2818.6) | 6431.6 (8.4) 6446.4(±542.6) | 8736.3 (36.5) 9141.3 (±3337.1) |
Albumin level (g/L)a n = 24 | Mean (±SD) | 33.9 (±3.1) | 34.2 (±5.6) | 33.2 (±4.6) | 32.5 (±4.9) |