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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: FOXQ1-mediated SIRT1 upregulation enhances stemness and radio-resistance of colorectal cancer cells and restores intestinal microbiota function by promoting β-catenin nuclear translocation

Fig. 3

Analysis of the correlation between FOXQ1 expression and CRC cell radio-resistance. A The survival rate of HCT116 and HT29 cells during fractionated irradiation to develop radiation-resistant CRC cells; B qRT-PCR was used to measure the mRNA expression of FOXQ1 in parent strains HCT116 and HT29 and the radiation-resistant strains HCT116R and HT29R (* p < 0.05 between two groups); C Western blot assay was used to measure the protein expression of FOXQ1 in parent strains HCT116 and HT29 and radiation-resistant strains HCT116R and HT29R (* p < 0.05 between two groups). All cell experiments were repeated for three times independently. The measurement data were expressed as mean ± standard deviation. One-way ANOVA was used for comparison among multiple groups, and Tukey’s test was selected for pairwise comparison within the group.

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