Fig. 2From: SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalancesSf3b1 is overexpressed in different electroporated (EPed)-glioma mouse models. a Generation of mouse models of GBM by plasmid DNA mix injection into the left lateral ventricle following mouse brain electroporation (adapted from [9]). b mRNA expression levels of Sf3b1 and, c ROC-curve analysis of Sf3b1, in the control and tumor samples of the EPed mouse model. d Correlation of Sf3b1 with different key prognostic biomarkers and relevant spliceosome components in GBM samples from these models. Asterisks (*P < 0.05; **P < 0.01) indicate statistically significant differences across different conditions. Plus symbol (+) indicates a tendency between conditions (+P > 0.05 < 0.1)Back to article page