Fig. 4

SF3B1 overexpression is associated with poor survival. Kaplan-Meier survival curves for GBM patients with high and low expression levels of SF3B1 in our cohort of patients (a), as well as in the Rembrandt (b) and CGGA (c) datasets. Comparison of expression levels of SF3B1 and heatmaps generated using SF3B1 levels between control samples and proneural, mesenchymal, and classical GBM subtypes from the Rembrandt (d) and CGGA (e) datasets. ROC-curve analyses of SF3B1 comparing classical/mesenchymal GBM vs. proneural GBM samples in the Rembrandt (f) and CGGA (g) datasets. h SF3B1 expression levels (upper panel) and heatmap (lower panel) discerning between neural precursor cells, proneural and mesenchymal-like tumors from EPed mouse models. Asterisks (*P < 0.05; **P < 0.01; ***P < 0.001) indicate statistically significant differences across different conditions. Plus symbol (+) indicates a tendency between conditions (+P > 0.05 < 0.1)