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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α degradation

Fig. 8

TRPM7 silencing shifts glycolysis to OXPHOS by modulating the AMPK / HIF-1α signaling in ovarian cancer cells. TRPM7 silencing can enhance the AMPK activation promote HIF-1α ubiquitination proteasomal degradation that attenuates the HIF-1α-enhanced glycolysis to shift glycolysis to OXPHOS, inhibiting ovarian cancer cell proliferation and tumor growth

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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