Fig. 2

NFAT1 regulates the multiple signaling pathways associated with the immune response in RCC. A and B 786-O cells were infected with the indicated constructs for 72 h. Cells were subjected to RNA-seq analysis. C Gene Set Enrichment Analysis of JAK-STAT signaling pathway, HIF-1 signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Toll-like signaling pathway, and IL-17 signaling pathway in NFAT1 silenced 786-O cells. D Gene Set Enrichment Analysis of PD-L1 expression and activation of PD-1 checkpoint pathway in NFAT1 silenced 786-O cells. E Heatmap to show the differential expressed genes of PD-L1 expression and activation of PD-1 checkpoint pathway in NFAT1 silenced 786-O cells