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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression

Fig. 7

A model depicted that FBW7 was a novel E3 ligase for GSK-3β-induced degradation of NFAT1, and NFAT1 increased TNF expression to upregulate PD-L1 expression in RCC cells. Then, overactivation of the PI3K/AKT/GSK-3β signaling pathway stabilized NFAT1 in sunitinib-resistant RCC cells. Furthermore, we found that downregulation of SETD2 and FOXA1 expression contributed to the decrease in FBW7 expression in sunitinib-resistant RCC cells. Thus, the FBW7/NFAT1 axis played a role in the RCC response to TKIs and ICIs

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