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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

Fig. 6

FTO and APOE regulate glycolysis of PTC by modulating IL-6/JAK2/STAT3 signaling pathway. a Differentially expressed gene profiles based on GSEA of si-FTO and si-NC RNA-seq data. b Differential gene profiles based on GSEA of APOE gene expression profile data of TCGA. c Expression levels of IL-6/JAK2/STAT3 signaling pathway related proteins as determined by western blotting after FTO knockdown in K1 cells. d Expression levels of IL-6/JAK2/STAT3 signaling pathway related proteins as determined by western blotting after FTO overexpression in TPC1 cells. e Expression levels of IL-6/JAK2/STAT3 signaling pathway related proteins as determined by western blotting after APOE knockdown in K1 cells. f Expression levels of IL-6/JAK2/STAT3 signaling pathway related proteins as determined by western blotting after APOE overexpression in TPC1 cells. g Expression levels of GLUT1 protein and IL-6/JAK2/STAT3 signaling pathway related proteins as determined by western blotting after co-transfection of si-FTO and si-APOE in K1 cells. h. Mechanism diagram of the relationship of FTO, m6A modification, PTC tumor growth and glycolysis metabolism. *P < 0.05, **P < 0.01

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