Fig. 5

DSP107 reduces tumor growth in vivo and has good safety profile in non human primates. A) Size of the tumor for each individual mice. Five mice were in the control group and six mice were in the treatment group. B) Average tumor volume in the control and treatment group, C) Average tumor weight in the control and treatment groups. D) Immunohistochemistry staining of CD3⁺ T cells infiltrating the tumor in the control group (top) and the treatment of DSP107 (bottom), scale bar: 20 μm. E) the Average number of T cells in tumor tissue calculated from pictures in the control and treatment groups. F) Average size of T cells in the control and treatment groups. For all the mice Figs. (A-E), unpaired one sided t-test was used to compare T cell infiltration in the control and treatment groups n.s. = p > 0.05, error bars represent SD. G) Concentration of hemoglobin in the blood of cynomolgus monkey after injection of various doses of DSP107 (0, 5, 15 and 50 mg/kg), H) RBC count in blood of cynomolgus monkey after injection of various doses of DSP107 (0, 5, 15 and 50 mg/kg), I) Platelets count in blood of cynomolgus monkey after injection of various doses of DSP107 (0, 5, 15 and 50 mg/kg), J) AST level in serum of cynomolgus monkey after injection of various doses of DSP107 (0, 5, 15 and 50 mg/kg), K) ALT level in serum of cynomolgus monkey after injection of various doses of DSP107 (0, 5, 15 and 50 mg/kg), L) Total lymphocyte count in blood of cynomolgus monkey after injection of various doses of DSP107 (0, 5, 15 and 50 mg/kg). Across the figure, t-test values: n.s. = p > 0.05, * = p < 0.05, ** = p < 0.01, *** = p < 0.001, all error bars in the figure represent SD