Fig. 1

Significant reduction of LINC00461 expression in response to MPT0B291 treatment in glioblastomas (GBMs). A Venn diagram depicts the number of differentially expressed lncRNAs selected by microarray analysis in stem-like (S-U87MG) and temozolomide (TMZ)-resistant (R-U87MG) GBM cells treated with MPT0B291 (MP, 10 μM in S-U87MG; 6 mM in R-U87MG) and DMSO, respectively, for 1 day. B Heatmap represents the significantly changed expression of long non-coding RNAs (lncRNAs; fold change ≥1.5) by MPT0B291 in the two microarray datasets in (A). The color scale indicates the relative fold change (log2) to control (DMSO) of each lncRNA, where red represents high expression and green represents low expression. Genes are hierarchically clustered based on their expression values. C RNA-seq revealed the discriminative expression of lncRNAs post HDAC6 knockdown. Y-axis represents relative expression level (log2) to control (si-NC) of each lncRNA shown in the x-axis. D Effect of MPT0B291 on LINC00461 expression in parental and TMZ-resistant U87MG cells after 1-2 days of treatment. The results are shown as mean ± standard error of the mean (SEM) for triplicate samples in each group. One-way ANOVA