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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells

Fig. 6

LINC00461 maintains the expression of cell-cycle-related proteins by sponging tumor-suppressive miRNAs. A Effect of MPT0B291 on the protein expression of cell-division-related genes at 48 h in parental and TMZ-resistant Pt#3 cells. Quantification of expression from triplicate samples is shown alongside the data. Unpaired Student’s t-test. B Effect of LINC00461 depletion on the protein expression levels of cell-division-related genes in parental and TMZ-resistant U87MG cells. Quantification of expression from triplicate samples is shown alongside the data. Unpaired Student’s t-test. C The combined effect of LINC00461 elevation and MPT0B291 treatment on the expression of miR-485-3p in parental and TMZ-resistant U87MG cells. Unpaired Student’s t-test. D The combined effect of LINC00461 elevation and MPT0B291 treatment on the expression of MELK in parental and TMZ-resistant U87MG cells. Unpaired Student’s t-test. E A schematic diagram illustrating how the HDAC6/RBP/LINC00461 axis maintains the expression of cell-cycle-related protein MELK by sponging tumor-suppressive miR-485-3p, but the HDAC6 inhibition induced by MPT0B291 is able to block LINC00461 functions, reducing GBM malignancy. The results are shown as mean ± SEM for triplicate samples in each group

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