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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription

Fig. 3

NFIL3 regulates cancer associated inflammation in breast cancer. A. Functional enrichment analysis of downregulated genes associated with 10 hallmarks of cancer upon knocking down NFIL3. B. Functional enrichment analysis of upregulated genes associated with 10 hallmarks of cancer upon knocking down NFIL3. C. Enrichment analysis of significantly changed genes associated with inflammatory pathways. The size of dots represents the number of genes in a specific inflammatory pathway. The color of the dots represents the enrichment degree of genes with a specific inflammatory pathway. D. The positive correlation between NFIL3 mRNA level and the infiltration of CD8+ T cells, activated CD4 memory T cells, M1 cells and activated DCs in the breast cancer was obtained by Pearson Correlation analysis based on the TCGA dataset (p < 0.05). E. The negative correlation between NFIL3 mRNA level and the infiltration of resting mast cells, regulatory T (Treg) cells, monocytes and M2 cells in the breast cancer was obtained by Pearson Correlation analysis based on the TCGA dataset (p < 0.05). F. The representative expression of NFIL3, CD8, CD68, CD163 and CD16 at protein level was detected by IHC (magnification, 100×, scale bars = 200 μm; magnification, 400×, scale bars = 50 μm). G. Pearson correlation analysis between the expression of NFIL3protein and the level of infiltrated CD8+ T cells, M1 and M2 cells in 60 TNBC tissues (p < 0.01)

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