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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway

Fig. 4

BD selectively inhibits the Nrf2 pathway. a-b Effects of BD on the protein level of Nrf2 in PDAC cells. Miapaca-2 and Capan-2 cells were treated with BD (0–1.5 µM) for 24 h. c-d BD (1.5 µM) treatment for the indicated time periods (0–24 h). e Immunofluorescence staining of endogenous Nrf2 in Miapaca-2 and Capan-2 cells treated with or without BD (1.5 µM) for 24 h. All images were shown at 20 µm. (f) BD docking with Keap-1 and Nrf2. The blue ribbon represents the Keap-1 amino acid chain, the red ribbon represents the Nrf2 amino acid, the green bonds represent the hydrogen bond. Val is the abbreviation of valine

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