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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway

Fig. 8

Knockdown of Nrf2 plus BD enhances the chemosensitivity to GEM in human PDAC cells. a Cell viability of the Nrf2-silenced and non-silenced Miapaca-2, PANC-1 and Capan-2 cells were measured by MTT assay. b Effects of Nrf2 knockdown on the protein levels of Nrf2, Keap1, HO-1, NQO1, γGCSm, AKR1B10, MRP1 and MRP5 in Miapaca-2, PANC-1 cells treated with BD and GEM. c The statistical analysis of relative protein level from Fig. 7b. Data were presented as the mean ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the control group

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