Fig. 9

BD suppresses the orthotopic PDAC tumor growth and sensitizes the efficacy to GEM by inhibiting Nrf2 pathway. a Schematic presentation of the experiments on orthotopic PDAC murine model. b The body weight of mice was measured every 4 days after injection of cells. c-d Representative images of tumor and the tumor weight (n = 6–7). e Representative image of H&E and IHC staining of the resected tumors (Scale bar: 50 μm). f Statistical graphs of the IHC staining of Ki67 and Nrf2. g Schematic diagram of the regulation of Nrf2 signaling by BD treatment in PDAC cells. Data were presented as the mean ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the control group; n.s., no significant. ^##p < 0.01 and ^###p < 0.001 compared with the GEM group