Fig. 3

Ablation of EMILIN-2 associates with a harsh inflammatory response. A Graph showing the weight of wild type (wt) and Emilin-2^−/− (E2^−/−) mice during the establishment of a sporadic model of CRC following 6 injections of AOM (red arrows), n = 5. B Graph indicating the number of colonic lesions present in wild type (wt) and Emilin-2^−/− (E2^−/−) mice after 16 weeks from the first AOM injection. C Representative H&E images of the tumors developed in wild type (wt) and Emilin-2^−/− (E2^−/−) mice as in B; magnification 400x; scale bar = 50 μm. D Graph representing the Disease Activity Index (DAI) of wild type (wt) and Emilin-2^−/− (E2^−/−) mice during repeated cycles of DSS administration (red boxes), n = 5. E Representative H&E images of severe colitis in wild type (wt) and Emilin-2^−/− (E2^−/−) mice after 12 weeks from the first DSS treatment. Magnification 400x; scale bar = 50 μm. Graphs in A, B and D represent the mean ± SD; P values were obtained using the paired Student’s t-test; * P < 0.05, **P < 0.01, ***P < 0.001, n.s.: P > 0.05