Fig. 8

The levels of EMILIN-2 associate with macrophage polarization. A Spearman’s analysis correlating the expression levels of EMILIN-2 with the macrophage markers (CCL3, CD86 and IL4R) in CRC patients from the TCGA COAD cohort (n = 477). B and C Spearman’s correlation analyses showing the association between EMILIN-2 and the M1 or M2 macrophages in the same cohort reported in A, respectively. In B and C, the density of M1 or M2 cells was evaluated with the timer2 tool. P < 0.05 values were considered statistically significant