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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Fig. 5

A Schematic illustration of PNP@R@M-T developed for efficient and selective reprogramming of M2-like macrophages and enhanced cancer immunotherapy via M2pep-mediated endocytosis. B-F Inhibitory effects of PNP@R@M-T on tumor growth in vivo. B Schematic illustration of induction and treatment of B16-OVA tumors in C57BL/6 mice. C Body weights of mice treated with PBS, R848, PNP@R, PNP@R@M-S, and PNP@R@M-T. D The survival rate was analyzed by the log-rank test (n = 10 mice). E B16-OVA tumor growth. n = 6 mice. F Macroscopic images of tumors taken 18 days after the initiation of treatment. Representative images from 6 mice per group are shown [28]

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