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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Recent advances in the developmental origin of neuroblastoma: an overview

Fig. 2

Cell fates and multistep differentiation processes in physiologic development of the sympatho-adrenal lineage in mice. Cell populations and transitions, here illustrated, are based on scRNA-seq studies with spatial transcriptomics and lineage tracing conducted in developing mouse embryos. In the developing AM there is a co-localization of sympathetic and SCP-derived components at different degrees of differentiation, outlined as solid painted circles. Cell type populations involved in physiologic development of the sympatho-adrenal lineage include cell progenitors, transient cells, and cells at different developmental stages toward the final differentiated cell types. Embryonic developmental mouse timeline expressed in days: E10.5, E11.5, E13.5. Basic cell icons have been retrieved from https://app.biorender.com and modified by Adobe Photoshop CC 2019

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