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Table 1 Specifier markers characterizing mouse sympatho-adrenal cell types

From: Recent advances in the developmental origin of neuroblastoma: an overview

MOUSE SYMPATHO-ADRENAL CELL TYPES

MARKERS

SNPCs

Ret Phox2b Ascl1 Mycn Hand2 Gata3

Sox10- Plp1-

Sympathoblasts extra-adrenal

Phox2b Mycn Th Dbh Ret Cart Cartpt

Sox10- Plp1- Sgc10- Ascl1 -

Sympathetic neurons/ganglia/SRG

Ret Scg10 Cart Ascl1 Phox2b Th Dbh

Sox10- Plp1-

SCPs

Sox10 Plp1 Ascl1 Phox2b

Ret-

Schwann cells

Sox10 Plp1 Gfap

Phox2b-

Bridge cells

Sox10 Plp1 Chga Penk Htr3a Ascl1 Phox2b

Th- Ret-

Immature chromaffin cells

Chga Chgb Penk Th Dbh

Sox10- Plp1- Ret-

Chromaffin cells

Chga Penk Ascl1 Phox2b Th Dbh

Sox10- Plp1- Ret-

Sympathoblasts intra-adrenal

Ret Cart Cartpt Phox2b Th Alk Hmx1 Prph

Sox10- Plp1-

Sympathetic neurons intra-adrenal

Ret Cart Ascl1 Phox2b Th

Sox10- Plp1-

  1. Specifier protein markers expressed in each cell population are typed in bold, whereas not expressed proteins are indicated with a - symbol