Fig. 2From: CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotypeCrenigacestat decreases CD90 expression in iCCA PDX tissues. A THY1 is downregulated in iCCA PDX tissues following treatment with Crenigacestat. Fold-change -2.49 and FDR = 0.01. B Representative images with immunofluorescence staining show downregulation of CD90 expression. Staining quantification was calculated as the mean of three images per tissue from PDX mice treated with Crenigacestat compared to vehicle. Mean ± SEM (number of PDX mice treated with vehicle = 10, number of PDX mice treated with Crenigacestat = 10). **p < 0.01; ***p < 0.001 calculated with Mann Whitney test. Magnifications: × 20Back to article page