Fig. 4From: HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulationDomatinostat sensitizes both PDAC stem cells and differentiated cells to chemotherapy. PANC1, PANC28 and ASPC1 cells were growing in differentiation condition (DIFF in blue) and as spheroids (CSCs in orange), then are treated for 72 h with domatinostat (1 μM) alone and in combination with gemcitabine/taxol (respectively, 12.5 nM and 1 nM). Cell growth expressed as percentage of control was assessed by Cell titer assay (see Materials and Methods). Statistically significant results by ANOVA test are reported (*** indicates P < 0.0001, ** indicates P < 0.005 and * indicates P < 0.05)Back to article page