Epigenetic remodelling in human hepatocellular carcinoma

Table 5 The most relevant hyper- and hypomethylated genes in HCC

Genes	DNA Methylation pattern in HCC	Reference
*HHIP, PTGR1, TMEM106A, MT1M, MT1E, CPS1, CDKN2A*	Hyper	[16]
*CDKN2A, MLH1, FZD7, SOCS1, APC, RASSF1*	Hyper	[107]
*HIST1H2AJ, SPDYA*	Hyper	[108]
*HRNBP3*	Hypo
*CDKN2A*	Hyper	[113]
*FZD7, CDKN2A, APC, RASSF1*	Hyper	[114]
*SOCS1, RASSF1*	Hyper	[115]
*CHFR, MGMT, RASSF1, GSTP1*	Hyper	[116]
*CDKN2A, BMP4, NFATC1, GSTP1*	Hyper	[117]
*APC, RASSF1*	Hyper	[118]
*IGF2*	Hypo
*SOCS1, APC, GSTP1*	Hyper	[119]
*SMAD6, IFITM1, LRRC4, CHST4, TBX15*	Hyper	[120]
*CCL20, NQO1*	Hypo
*p16, CDH1, p15, RUNX3, SFRP1, PRDM2, p14, RARβ, DAPK1, SOCS1, APC, RASSF1, MGMT, GSTP1*	Hyper	[121]
*OCIAD2*	Hyper	[122]
*RASSF1A*	Hyper	[123]
*CDCA1, CDCA3, CDCA4, CDCA5, CDCA6, CDCA8*	Hypo	[124]
*CDCA2, CDCA7*	Hyper
*MTFR2*	Hyper	[125]

ISSN: 1756-9966