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Table 6 Epigenetics drugs in trial for HCC

From: Epigenetic remodelling in human hepatocellular carcinoma

DRUGS

Phase

Reference

DNMTi

Guadecitabine (SGI-110) after sorafenib

Phase II

NCT01752933

Guadecitabine (SGI-110) + durvalumab

Phase Ib

NCT03257761

HDACi

Belinostat (PDX-101)

Phase I/II

NCT00321594

Tefinostat

Phase I/II

NCT02759601

Vorinostat + FOLFIRI

Phase I

NCT00537121

Panobinostat + sorafenib

Phase I

NCT00823290

Panobinostat + sorafenib

Phase I

NCT00873002

Resminostat + sorafenib

Phase II

NCT00943449

Resminostat + sorafenib

Phase I/II

NCT02400788

Vorinostat + sorafenib

Phase I

NCT01075113