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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling

Fig. 7

CircSCAP inhibits the malignance of NSCLC by downregulating SF3A3 in vitro and in vivo. A-B NSCLC cells with circSCAP stable overexpression exhibited weakened proliferation (A) and colony formation ability (B) when compared with control, while SF3A3 could rescue the phenotype, as shown by CCK8 and colony formation assay. C In vivo growth curve (upper panel), and weight at the end points (lower panel) of xenograft tumors formed by subcutaneous injection of NSCLC cells co-transfected with circSCAP and/or SF3A3 into the dorsal flanks of nude mice (n = 3 for each group). D Relative expression level of circSCAP and SF3A3 in subcutaneous xenografts of nude mice with the indicated treatment were determined via RT-PCR. E–F Representative image (E) and quantification (F) of immunohistochemical staining showing the expression of Ki-67 and SF3A3 of xenografts (n = 3 for each group). Scale bars: 50 μm. * means P < 0.05. ** means P < 0.01, *** means P < 0.001

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